The Ethiopian Primary Health Care Clinical Guidelines is an integrated symptom-based algorithmic approach to address the common presenting symptoms and priority chronic conditions in the country. The scope of what is covered in chronic conditions for adults and long-term health conditions for older children includes: cardiovascular diseases; diabetes; chronic respiratory diseases; mental health musculoskeletal disorders; and women’s health. The Guidelines provides basic management principles to deal with these diseases at a health center level in an integrated user-friendly way to support health workers to provide care that is evidence-informed compliant with local guidelines comprehensive compassionate and respectful.